On November 15, 2017, Towns had 26 points and 16 rebounds for Minnesota on the night he turned 22, helping the Timberwolves end a 12-game losing streak to the San Antonio Spurs with a 98–86 victory. Towns finished in the top 10 in almost every statistical category in NBA history compiled prior to the player's 22nd birthday. He ranked eighth in points, third in rebounds and second in double-doubles (124), trailing only Dwight Howard (169). Towns subsequently earned Western Conference Player of the Week honors for games played from Monday, November 13 through Sunday, November 19. On December 14, 2017 against the Sacramento Kings, Towns had 30 points, 14 rebounds, five assists and five blocks, joining Kevin Garnett as the only Wolves players to collect 30+ points, 10+ rebounds, 5+ assists and 5+ blocks in a single game. On December 31, 2017, he had 18 points, 14 rebounds and a career high-tying six blocks in a 107–90 win over the Indiana Pacers. On January 5, 2018, he recorded 25 points and a career-high 23 rebounds in a 91–84 loss to the Boston Celtics. On January 12, 2018, Towns fell one assist shy of his second career triple-double, scoring 23 points and grabbing 15 rebounds in the Timberwolves' 118–108 victory over the New York Knicks. On January 23, 2018, he was named a Western Conference All-Star reserve. On March 11, 2018, he recorded 31 points and 16 rebounds in a 109–103 win over the Golden State Warriors. Two days later, he scored a season-high 37 points in a 116–111 win over the Washington Wizards. On March 20, 2018, he recorded his NBA-best 60th double-double with 30 points and 10 rebounds in a 123–109 win over the Los Angeles Clippers. On March 28, 2018, he scored a franchise-record 56 points and added 15 rebounds for his league-leading 63rd double-double, as the Timberwolves beat the Atlanta Hawks 126–114. The 56 points surpassed Mo Williams' franchise record of 52 points set on January 13, 2015, against the Indiana Pacers. He also became the youngest player (22 years, 133 days) with 50 points and 15 rebounds in a game since Shaquille O'Neal (22 years, 45 days) on April 20, 1994 against the Timberwolves. In the Timberwolves' regular season finale on April 11, 2018, Towns had 26 points and 14 rebounds in a 112–106 overtime win over the Denver Nuggets. The win clinched Minnesota a spot in the playoffs for the first time since 2004—no team in the league had gone longer without a postseason appearance than the Timberwolves. It was the first final-day play-in game in the NBA in 21 years, with Denver also vying for a spot in the playoffs. Towns finished the season with 68 double-doubles, the most in the NBA. In Game 3 of the Timberwolves' first-round playoff series against the Houston Rockets, Towns recorded 18 points and 16 rebounds in a 121–105 win. The Timberwolves went on to lose the series in five games, despite Towns recording 23 points and 14 rebounds in a 122–104 loss in Game 5.